Akademik Veri Yönetim Sistemi
KOLAYLI S. (Yürütücü), ALVER A., YENİLMEZ E., KEMAL M.
Yükseköğretim Kurumları Destekli Proje, 2021 - 2024
This study investigates the antiobesity effects of water-based Anatolian propolis extract (SBAP) in mice with a cafeteria diet (CAF)-induced obesity model. The phenolic composition and antioxidant capacity of propolis extract were measured. In addition, the inhibitory effect on α-amylase and α-glucosidase enzymes was investigated. 42 male C57BL/6 mice were used. The control group (n=6) and the study group (n=36) were fed theCAF diet for 12 weeks. SBAP and Orlistat® were administered intraperitoneally to obese mice for 4 weeks. Serum samples were collected at the end of the 28th day after decapitation.Serum insulin, leptin, adiponectin, TNFα, IL-6 and UCP-1 were analysed by ELISA, and serum biochemical parameters were analysed by autoanalyzer. Liver and adipose tissues were also subjected to histopathological analysis. Significant reductions in body weight,triglyceride, AST, ALT, HOMA-IR, leptin and TNFα levels were observed in the SBAP treated experimental group compared to the obese cafeteria group. In addition, there was a significant increase in adiponectin levels in the SBAP-treated group compared with the obese cafeteria group. In conclusion, the results showed that propolis extracts are a promising natural and alternative product for the treatment of obesity