Sıçanlarda Siyatik Sinir Hasarıyla Tetiklenen Deneysel Nöropatiye Karşı Korteksinin Olası Protektif Etkisinin Fonksiyonel Yapısal ve Moleküler İncelenmesi


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YAZAR U. (Executive), TOPSAKAL A. S., AYAR A., GÜVERCİN A. R., ÇAKIR E., AKTAŞ O.

Project Supported by Higher Education Institutions, 2020 - 2023

  • Project Type: Project Supported by Higher Education Institutions
  • Begin Date: August 2020
  • End Date: December 2023

Project Abstract

As a result of injuries such as traffic accidents, a number of people experience movement disorders, even paralysis, and there is still no effective treatment for this conditions. Compression, excessive stretching, crushing or cutting of the sciatic nerve which is the largest nerve in the body, causes pain in the region from the underside of the spine to the direction of the back of the legs, loss of muscle strength and sensory impairments. The cortexin (Turkish: korteksin), a drug containing hydrolyzed brain peptides, was discovered in Russia and has been used in the treatment for a long time. However, its effect on the problems due to sciatic nerve damage has not been studied yet. Within the scope of this project, sciatic nerve damage was surgically induced in rats as experimental animals and the possible healing effects of the cortexin were examined by measuring the strength in the muscle stimulated by the nerve and the pain triggered by heat and mechanical stimulation in the affected leg. In addition, the related nerve of cortexin-treated rats was examined by histopathologic examinations and molecular markers were analyzed by advanced techniques. Accordingly, it was concluded that cortexin has ameliorative effects on sciatic nerve damage in a dose-dependent manner.