The Value of Signal Peptide-CUB-EGF Domain-containing Protein-1 (SCUBE1) in the Diagnosis of Pulmonary Embolism: A Preliminary Study

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Turkmen S., Şahin A., Gunaydin M., Sahın S., Menteşe A., Türedi S., ...More

ACADEMIC EMERGENCY MEDICINE, vol.22, no.8, pp.922-926, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.1111/acem.12721
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.922-926
  • Karadeniz Technical University Affiliated: Yes


ObjectivesThe diagnosis of pulmonary embolism (PE) in the emergency department still poses difficulties because symptoms and signs are nonspecific. There is a need for more reliable noninvasive diagnostic tests to support clinical suspicion before the costly invasive procedures with complication risks still used in the diagnosis of PE. Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1 (SCUBE1) is a novel, secreted cell surface protein expressed during early embryogenesis. The goal of this study was to compare the SCUBE1 levels between PE patients and healthy subjects and also investigate the value of SCUBE1 in the diagnosis of PE.