DNA binding, antioxidant and antimicrobial activities of homo- and heteronuclear copper(II) and nickel(II) complexes with new oxime-type ligands

ÇOLAK A., TERZI U., COL M., KARAOGLU S. A., KARABÖCEK S., KUCUKDUMLU A., ...More

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.45, no.11, pp.5169-5175, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 11
  • Publication Date: 2010
  • Doi Number: 10.1016/j.ejmech.2010.08.031
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5169-5175
  • Keywords: Antioxidant, Antimicrobial, DNA binding, Oxime-type ligand, SOD mimics, CALF THYMUS DNA, SUPEROXIDE-DISMUTASE, BIOLOGICAL-ACTIVITY, CRYSTAL-STRUCTURE, AUXILIARY LIGAND, METAL-COMPLEXES, CU(II) COMPLEX, SOD ACTIVITIES, CLEAVAGE, MIMICS
  • Karadeniz Technical University Affiliated: Yes

Abstract

Some homo- and heteronuclear Cu(II) and Ni(II) complexes of new oxime-type ligands were tested against several pathogenic microorganisms to assess their antimicrobial potentials. The antimicrobial activities of complexes were evaluated in terms of minimum inhibitory concentration (MIC; mu g/mu L) and it was observed that the complexes possess moderate antimicrobial properties. The binding of the complexes with DNA were also investigated by using UV-Vis spectroscopy. It was seen that three of the complexes could bind to DNA through an intercalative mode while the other complexes could have other mechanisms. Furthermore, the antioxidant efficiencies of the metal complexes were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radical scavening activities. Due to the observed IC(50) values, they are potential drugs to eliminate the radicals. (C) 2010 Elsevier Masson SAS. All rights reserved.