Evaluation of implementation of evolving practice patterns in the first-line treatment of patients with metastatic non-small cell lung cancer in Turkiye (ESTIMATE): a national, multicenter, retrospective, real-world evidence study

ŞENDUR M. A. N., Karadurmus N., Cicin I., GÜMÜŞ M., Demirci U., Ozyilkan O., ...More

FUTURE ONCOLOGY, vol.21, no.19, pp.2525-2535, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 19
  • Publication Date: 2025
  • Doi Number: 10.1080/14796694.2025.2527477
  • Journal Name: FUTURE ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.2525-2535
  • Karadeniz Technical University Affiliated: Yes

Abstract

BackgroundThis national, multicenter, retrospective, non-interventional real-world evidence study aimed to address patient characteristics and systemic treatment practices of metastatic non-small cell lung cancer (mNSCLC) patients in T & uuml;rkiye.Research design and methodsOver 6 months, 636 adults with mNSCLC at 12 Turkish oncology centers provided retrospective data.ResultsAdenocarcinoma was the most common histology, with 95% having distant bone metastases and 64.8% having no comorbidities. The most frequently administered first-line therapy was combination chemotherapy followed by targeted therapy and immunotherapy. Overall, 55.5-69.3% of patients were tested for ALK, EGFR, ROS1, and PD-L1.ConclusionsBiomarker screening in mNSCLC patients in T & uuml;rkiye was suboptimal compared to other countries, especially in public hospitals.