SYNTHESIS AND <i>IN</i>-<i>VITRO</i> ANTIOXIDANT EVALUATION OF SOME NOVEL 4-(4-SUBSTITUTED) BENZYLIDENAMINO-4,5-DIHYDRO-1<i>H</i>-1,2,4-TRIAZOL-5-ONES

Yuksek H., GÜRSOY KOL Ö., Kemer G., Ocak Z., Anil B.

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, no.4, pp.325-330, 2011 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Publication Date: 2011
  • Journal Name: INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.325-330
  • Karadeniz Technical University Affiliated: No

Abstract

3-Alkyl (aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2a-g) were reacted with 4-ethylbenzaldehyde to afford the corresponding 3-alkyl (aryl)-4-(4-ethylbenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3a-g). The acetylation reactions of compounds 3 were also investigated and compounds 4a-c, 4e, 4f were obtained. The new twelve compounds were characterized using IR, H-1 NMR, C-13 NMR and UV spectral data. In addition, 3 and 4 type compounds were screened for their antioxidant activities. Moreover compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide in four nonaqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetone, N,N-dimethylformamide and the halfneutralization potential values and the corresponding pKa values were determined in all cases.