Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis

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Türkyılmaz S., Çekiç A. B., Usta A., Alhan E., Kural B., Ercin C., ...More

ARCHIVES OF MEDICAL SCIENCE, vol.15, no.1, pp.232-239, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.5114/aoms.2017.65231
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.232-239
  • Keywords: pancreatitis, rat, ethyl pyruvate, acute necrotizing pancreatitis, IMPROVES SURVIVAL, OXIDATIVE STRESS, FREE-RADICALS, LIVER-INJURY, ACCUMULATION, PATHOGENESIS, ISCHEMIA
  • Karadeniz Technical University Affiliated: Yes

Abstract

Introduction: Ethyl pyruvate (EP), a natural flavoring and fragrance agent, has been shown to exert anti-inflammatory and antioxidant actions. We tested the potential beneficial effects of EP in a rat model of acute necrotizing pancreatitis (ANP), a serious condition with a significant inflammatory explosion and oxidative stress.