Potential therapeutic effects of ethyl pyruvate and N-acetyl cysteine in an experimental rat model of corrosive esophageal


TATLI Ö. , Pasli S., Imamoglu M., Cicek M., Yadigaroglu M., ŞAHİN A. , ...More

ARAB JOURNAL OF GASTROENTEROLOGY, vol.21, no.4, pp.260-266, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1016/j.ajg.2020.10.001
  • Title of Journal : ARAB JOURNAL OF GASTROENTEROLOGY
  • Page Numbers: pp.260-266
  • Keywords: Alkali burn, Corrosive substance, Esophagus, Ethyl pyruvate, N-acetyl cysteine, NaOH, ISCHEMIA-REPERFUSION INJURY, BURNS, ACETYLCYSTEINE, STRICTURES, MANAGEMENT, ACID, CHILDREN

Abstract

Background and study aims: Esophageal burns due to ingestion of corrosive substances are frequently seen in both children and adults. However, there is no standard method of treatment to prevent associated mortality and morbidity. Therefore, this study aimed to evaluate the effects of known antioxidants, namely N-acetyl cysteine and ethyl pyruvate, on esophageal damage due to sodium hydroxide-induced corrosive burns.