JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.55, no.12, pp.2744-2759, 2018 (SCI-Expanded)
Azole derivatives (10a-f) obtained starting from 1-(4-fluorohenyl)piperazine were converted to the corresponding Mannich bases (7a-d, 12a,b, and 16a,b) containing beta-lactame or flouroquinolone core via a one-pot three-component reaction. The synthesis of conazole analogues was carried out starting from triazole by three steps. Reactions were carried out under conventional-mediated and microwave-mediated conditions. All the newly synthesized compounds were screened for their antimicrobial, antioxidant activity, and most of them displayed good-moderate activity.