Biscarbazole Derivatives: Synthesis, Characterization, Antimicrobial and Antitumor Activity, and Molecular Docking Study

Çelik F., Aydın A., İnan Bektaş K., Güler H. İ., Nalçaoğlu A., Ünver Y.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY, vol.92, no.10, pp.2145-2160, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 92 Issue: 10
  • Publication Date: 2022
  • Doi Number: 10.1134/s1070363222100279
  • Journal Name: RUSSIAN JOURNAL OF GENERAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Index Chemicus (IC)
  • Page Numbers: pp.2145-2160
  • Keywords: carbazole, amine, imine, antimicrobial activity, antitumor activity, docking study, SCHIFF-BASE, CARBAZOLE, INHIBITION
  • Karadeniz Technical University Affiliated: Yes

Abstract

New series of biscarbazole derivatives containing imine-amine groups was synthesized. Antimicrobial activity of newly synthesized compounds against bacterial strains and yeast isolates was determined. The effects of the synthesized test compounds on cell proliferation and NCI-60 survival parameter values were measured. In addition, in silico analysis against five different receptors with synthesized two compounds was carried out to see the necessary interactions responsible for anti-bacterial activity. The docking results of both compounds supported the antibacterial activity exhibiting high inhibition constants.