Anti-Carbonic Anhydrase II Antibodies in End-Stage Renal Disease Patients

ALVER A., MENTEŞE A., Mentese U., Sumer A., Ucar F., Altay D. U.

MEDICAL PRINCIPLES AND PRACTICE, vol.23, no.4, pp.331-335, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1159/000362667
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.331-335
  • Keywords: End-stage renal disease, Carbonic anhydrase II, Malondialdehyde, Autoimmunity, Ghrelin, AUTOIMMUNE PANCREATITIS, HELICOBACTER-PYLORI, OXIDATIVE STRESS, GHRELIN, AUTOANTIBODIES, ERYTHROCYTES
  • Karadeniz Technical University Affiliated: Yes


Objective: The aim of this study was to investigate the presence of anti-carbonic anhydrase (CA II) autoantibodies in patients with end-stage renal disease (ESRD) and relationships between the autoantibody titers and ghrelin, glucose, blood urea nitrogen (BUN) and creatinine. Subjects and Methods: Serum CA II autoantibody titers, malondialdehyde (MDA), BUN, creatinine and ghrelin levels were measured in 45 ESRD patients and 45 healthy subjects. Results: The CA II autoantibody titers in the ESRD group (0.170 +/- 0.237) were significantly higher than those in the control group (0.079 +/- 0.032; p = 0.035). MDA and ghrelin levels were also significantly higher in the ESRD group (p < 0.001). A weak positive correlation was determined between anti-CA II antibody titers and MDA, and a negative correlation was observed between ghrelin levels and anti-CA II antibody titers (r = 0.287, p = 0.028 and r = -0.278, p = 0.032, respectively). Conclusions: In ESRD patients, the results showed the development of an autoimmune response against CA II. This suggests that anti-CA II antibodies could be involved in the pathogenesis of ESRD. (C) 2014 S. Karger AG, Basel