Pipelines are one of the most effective methods of transferring energy sources like petroleum and gas. In pipeline projects, decreasing the cost, reducing environmental issues and shortening the construction time are related to determining the right route at the beginning of the project. Route determination is usually carried out manually with the help of traditional methods. However; this technique is not effective in many situations because it does not evaluate the factors that affect the route as a whole. In fact, technique, economy, environmental and sociological issues should be examined as a whole in the route determination process. Evaluation of the factors affecting the route is possible with the analysis of many spatial datasets from the same system. Geographical Information Systems (GIS) have been shown to be an effective way for analyzing these types of intensive datasets. In this study, a suggestion related to the NABUCCO Natural Gas Transmission Pipeline project has been made using the Analytic Hierarchy Process (AHP), which is a technique using GIS and multi-criteria decision making. The effectiveness of this method was proven by comparing part of the determined Optimal Route with a length of 557 km with the Proposed Route, which has currently been planned.