Synthesis and <i>In Vitro</i> Antioxidant Evaluation of Some Novel 4, 5-Dihydro-1<i>H</i>-1, 2, 4-triazol-5-one Derivatives

GÜRSOY KOL Ö., Yuksek H.

E-JOURNAL OF CHEMISTRY, vol.7, no.1, pp.123-136, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1155/2010/407603
  • Journal Name: E-JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.123-136
  • Karadeniz Technical University Affiliated: No

Abstract

In this study, thirteen novel 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives were synthesized and characterized by elemental analyses and IR, H-1 NMR, C-13 NMR and UV spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Those antioxidant activities were compared to standard antioxidants such as BHA, BHT and alpha-tocopherol. The data reveal that the compounds demonstrate a marked capacity for iron binding, especially 5a and 7c. In addition to this, the compounds 4 were titrated potentiometrically with TBAH in non-aqueous solvents because of the weak acidic properties of 4,5-dihydro-1H-1,2,4-triazol-5-one ring N-H group.