Synthesis, biological activity and structure activity relationship studies of novel conazole analogues via conventional, microwave and ultrasound mediated techniques

MERMER A., DEMİRBAŞ N., DEMİRBAŞ A., ÇOLAK N., AYAZ F. A., Alagumuthu M., ...More

BIOORGANIC CHEMISTRY, vol.81, pp.55-70, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81
  • Publication Date: 2018
  • Doi Number: 10.1016/j.bioorg.2018.07.036
  • Journal Name: BIOORGANIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.55-70
  • Keywords: alpha-Glucosidase activity, Antimicrobial, Antioxidants, Conazole, Microwave irradiation, Molecular docking, Ultrasound sonication, Urease activity, GLUCOSIDASE INHIBITION, ANTIMICROBIAL ACTIVITY, ASSISTED SYNTHESIS, MOLECULAR DOCKING, ORGANIC-SYNTHESIS, HYBRID MOLECULES, DRUG-RESISTANCE, SOLVENT-FREE, DERIVATIVES, DISCOVERY
  • Karadeniz Technical University Affiliated: Yes

Abstract

1,2,4-Triazole derivatives containing a piperazine nucleus (4a-d and 10) were prepared starting from 1-(2-methoxyphenyl)piperazine or ethyl 4-(4-amino-2-fluorophenyepiperazine-1-carboxylate via several steps. The synthesis of fifteen compounds (7a-1 and 13a-c), which can be considered as new analogues of azole class antifungals was performed starting from 1,2,4-triazoles (4a-d and 10) via three steps containing the condensation with 2-bromo-1-(4-chlorophenyl)ethanone, reduction of carbonyl group to alcohol and alkylation of OH group, respectively. All the reactions were examined under conventional, ultrasound and microwave irradiation conditions as green chemistry techniques, and optimum conditions were defined. The newly synthesized compounds were screened for their biological potentials including antimicrobial, antioxidant, antiurease and anti a-glucosidase activities and promising results were obtained. The enzyme inhibitory potentials of these compounds were further validated through molecular docking.