Sequence Variant in the LPIN1 gene in Patients with Metabolic Syndrome

KURAL B. V., DEĞER O., Erem C., YUCESAN F., Barlak Y., Turan I., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.38, no.3, pp.280-285, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.5505/tjb.2013.41033
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.280-285
  • Keywords: metabolic syndrome, LPIN1, lipin-1, INSULIN-RESISTANCE, LIPIN, ASSOCIATION, POLYMORPHISMS, BIOSYNTHESIS, OBESITY, FAMILY, ROLES
  • Karadeniz Technical University Affiliated: Yes

Abstract

Objective: Metabolic syndrome (MetS) is a complex disease characterized by insulin resistance, abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia and low HDL-cholesterol level. The aim of the study was to evaluate the sequence variations in the LPIN1 gene in MetS. This gene codes lipin-1 protein which functions as Mg-dependent phosphatidic phosphatase enzyme and transcriptional coactivator.