Protective effects of L-theanine against doxorubicin-induced nephrotoxicity in rats

Altinkaynak Y., KURAL B., Akcan B. A., Bodur A., ÖZER YAMAN S., YULUĞ E., ...More

BIOMEDICINE & PHARMACOTHERAPY, vol.108, pp.1524-1534, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 108
  • Publication Date: 2018
  • Doi Number: 10.1016/j.biopha.2018.09.171
  • Journal Name: BIOMEDICINE & PHARMACOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1524-1534
  • Keywords: Antioxidant, Apoptosis, Glutathione, Inflammation, L-Theanine, CISPLATIN-INDUCED NEPHROTOXICITY, GAMMA-GLUTAMYL-TRANSPEPTIDASE, ACUTE KIDNEY INJURY, UNIQUE AMINO-ACID, OXIDATIVE STRESS, INDUCED NEUROTOXICITY, UP-REGULATION, LIVER-INJURY, GLUTATHIONE, METABOLISM
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background/aim: L-theanine is the unique amino acid found in tea plants, has antioxidant and antiinflammatory activities, and functions in mental concentration and sleep quality. In this study, it is aimed to investigate the effects of L-theanine on doxorubicin (DOX, a chemotherapeutic agent) induced nephrotoxicity in rats, especially via GSH related enzymes.