Synthesis of Some Novel 1,2,4-Triazol-3-one Derivatives Bearing the Salicyl Moiety and Their Anticonvulsant Activities
ARCHIV DER PHARMAZIE, cilt.347, sa.6, ss.449-455, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 347 Sayı: 6
- Basım Tarihi: 2014
- Doi Numarası: 10.1002/ardp.201300427
- Dergi Adı: ARCHIV DER PHARMAZIE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.449-455
- Anahtar Kelimeler: Anticonvulsant activity, Microwave irradiation, Salicyl aldehyde, Triazol-3-one, MICROWAVE-ASSISTED SYNTHESIS, ANTIFUNGAL ACTIVITY, TOXICITY
- Karadeniz Teknik Üniversitesi Adresli: Evet
Özet
A series of new 1,2,4-triazole-3-one derivatives bearing the salicyl moiety were synthesized by using microwave irradiation, and their chemical structures were identified by IR, H-1 NMR, C-13 NMR, elemental analysis, and LC-MS. The anticonvulsant activities of the compounds 4a-c, 4e, and 5a-e were evaluated by the Anticonvulsant Screening Program of the National Institute of Health, USA. The compounds had moderate anticonvulsant activities in the maximum electroshock-induced seizure and minimal clonic seizure models in mice, without any neurotoxic effects.