Synthesis, Characterization and Biological Activities of New Symmetric Bis-1,2,3-Triazoles with Click Chemistry

ÇELİK F., ÜNVER Y., Barut B., ÖZEL A., SANCAK K.

MEDICINAL CHEMISTRY, cilt.14, sa.3, ss.230-241, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1573406413666171120165226
  • Dergi Adı: MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.230-241
  • Anahtar Kelimeler: 1,2,3-Triazole, anti-allergic, antimicrobial, antioxidant, click chemistry, enzyme inhibition, ANTIOXIDANT ACTIVITIES, IN-VITRO, MYCOBACTERIUM-TUBERCULOSIS, ANTIMICROBIAL AGENTS, ANTIFUNGAL ACTIVITY, POTENT INHIBITORS, CYCLOADDITION, 1,2,3-TRIAZOLES, DESIGN, RING
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: 1,2,3-Triazole and its derivatives have important biological activities such as antimicrobial, anti-allergic, analgesic, anti-HIV, antiinflammatory, anticancer, antimalarial and antituberculosis. Other significant triazole derivatives are 1,2,4-triazoles which play a very important role in the medicinal chemistry due to the antiinflammatory, antimicrobial, antimigraine, anticancer, antimicrobial and antimycotic activities. In this study, we aimed to synthesize a new series of bis-1,2,3-triazole derivatives including 1,2,4-triazole to obtain more effective biological activities.