Ischemia-Modified Albumin as an Early Diagnostic Marker for Acute Renal Ischemia and Infarction

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TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.30, no.4, pp.1230-1235, 2010 (SCI-Expanded) identifier identifier


Objective: Acute renal infarction is a condition seldom encountered in emergency departments and it is generally diagnosed by chance when considering other diagnoses. This study investigates whether or not serum ischemia-modified albumin (IMA) levels rise in rats subjected to renal ischemia and infarction produced by clamping of the renal artery. Material and Methods: In this randomized, controlled and non-blinded trial, 24 mature male Wistar rats were divided into four, as two control groups (Groups I and III) and two intervention groups (Groups II and IV). In the control groups, blood was sampled in Group I at the 30th minute and in Group III at the sixth hour, following a simple laparotomy. In intervention groups II and IV, the renal artery was ligated leading to ischemia, and blood samples were taken at the 30th minute and sixth hour, respectively. Results: No difference was determined in terms of IMA levels in blood samples taken from the control and ischemia groups at the 30th minute (p= 0.12), although plasma IMA levels in the ischemia groups were significantly higher compared to those of the control groups in the 6th hour blood samples (p= 0.01). In addition, in the ischemia group, sixth hour blood sample levels were higher than the 30th minute sample levels (p= 0.011). Conclusion: Our preliminary findings suggest that there is no significant rise in IMA levels in the hyperacute period (first 30 minutes) of acute renal ischemia, however IMA levels measured at the sixth hour may represent a significant diagnostic parameter altough further studies are necessary.