OXIDATIVE STRESS AND SERUM S100B LEVELS IN ADOLESCENTS WITH FIRST-EPISODE DRUG-NAIVE UNIPOLAR DEPRESSION

Creative Commons License

BİLGİNER S. Ç., YAMAN H., Karadeniz S., Bulut S. H., Yaman S. O., AYDOĞDU S.

PSYCHIATRIA DANUBINA, cilt.33, sa.2, ss.158-164, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.24869/psyd.2021.158
  • Dergi Adı: PSYCHIATRIA DANUBINA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, EMBASE, MEDLINE, Psycinfo, Social services abstracts
  • Sayfa Sayıları: ss.158-164
  • Anahtar Kelimeler: unipolar depression, adolescent, SlOOB, oxidative stress, gender, MAJOR DEPRESSION, CHILD, DISORDER, EPISODES, SUPPORT, GENDER, SCALE
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: Unipolar depression is common among adolescents and has high recurrence rates. Studies conducted with adults show that oxidative stress plays a role in etiology of depression but studies with adolescent patients are limited. In addition, baseline S100B level in adult patients with depression is considered as a marker of response to treatment. The purpose of this study was to measure the levels of serum S100B, Malondialdehyde (DA), total oxidant status (TOS), and total antioxidant status (TAS), which have not been previously investigated in adolescent patients with first-episode, drug-naive unipolar depression, and to investigate the relationship of these parameters with disease severity and patient-specific variables.