Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents

MENTEŞE M., DEMİRBAŞ N., MERMER A., Demirci S., DEMİRBAŞ A., AYAZ F. A.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.15, sa.1, ss.46-64, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1570180814666170823163540
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.46-64
  • Anahtar Kelimeler: Fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole, piperazine, antibacterial activity, antioxidant activity, microwave, BIOLOGICAL-ACTIVITIES, DNA GYRASE, ASSISTED SYNTHESIS, 1,2,4-TRIAZOLE-CIPROFLOXACIN HYBRIDS, ANTIMICROBIAL ACTIVITIES, ATPASE INHIBITORS, PENICILLANIC ACID, DERIVATIVES, FLUOROQUINOLONES, MOLECULES
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: The synthesis of new hybrid molecules consisting of several heterocyclic pharmacophores namely fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole and piperazine was carried out by conventional and successfully optimized microwave mediated techniques.