Lung Carcinoma Developing Afatinib-Associated Skin Reactions


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Karaman E., Ulaş A., Adiacar Sezer A.

Journal of Oncological Science, vol.9, no.2, pp.112-116, 2023 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.37047/jos.2022-92025
  • Journal Name: Journal of Oncological Science
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.112-116
  • Keywords: Afatinib, epidermal growth factor receptor, hand-foot syndrome, lung adenocarcinoma, paronychia
  • Karadeniz Technical University Affiliated: Yes

Abstract

Afatinib is an irreversible second-generation tyrosine kinase inhibitor. It is used to treat epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma. The most well-known side effects associated with afatinib are diarrhea, rashes or acne and stomati-tis. Herein, we present a case of skin toxicity that developed in the late phase of afatinib treatment. A 51-year-old, non-smoker woman diagnosed with EGFR deletion-19 mutant advanced lung adenocarcinoma. Afatinib was initiated as the first-line treatment. At the twelfth treatment month, Grade-2 acneiform dermatitis, paronychia, and hand-foot syndrome developed. Despite the interruption or discontinuation of afatinib treatment and local/systemic steroid treatments, the lesions did not regress. The patient was responsive to afatinib; however, the treatment was discontinued in the eighteenth month of treatment. The treatment response may be predicted by the severity of skin toxicities owing to afa-tinib. They occur in the early treatment phase and are commonly observed at the Grade 1-2 level.