The evaluation of autoantibodies against oxidatively modified low-density lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids and lipid hydroperoxide levels, total antioxidant status, antioxidant enzyme activities, and endothelial dysfunction in patients with Behcet's disease

Orem A., Yandı Y. E., Vanizor B., Cimsit G., Uydu H. A., Malkoc M.

CLINICAL BIOCHEMISTRY, vol.35, no.3, pp.217-224, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1016/s0009-9120(02)00290-4
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.217-224
  • Keywords: Behcet's disease, autoantibodies against oxidized LDL, susceptibility of LDL to oxidation, total antioxidant status, antioxidant enzymes, lipid hydroperoxide, endothelial dysfunction, ICAM-1, PAI-1, OXIDIZED LDL, FREE-RADICALS, ANTIBODIES, RISK, ATHEROSCLEROSIS, PEROXIDATION, CONSEQUENCE, LEUKOCYTES, EXPRESSION, PSORIASIS
  • Karadeniz Technical University Affiliated: Yes

Abstract

Objectives: Behcet's disease is a multisystem disorder characterized by a chronic inflammation including acute attacks and remission periods. Decreased enzyme activity of the antioxidant system and increased levels of free radicals may have important roles in the damage of tissues observed in the disease period. In addition, the atherogenic tendency of serum lipid, lipoproteins, lipid peroxidation levels and endothelial dysfunction accompany the above mentioned findings. As a consequence of these events. different degrees of low density lipoprotein (LDL) oxidation occur in vivo, and then autoantibodies against oxidized-LDL(AuAb-oxLDL) are produced.