Hazelnut-enriched diet effectively increases lipoproteins' resistance to oxidation in hypercholesterolemic subjects


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AKCAN B., ÖREM A., KURAL B. V., altinkaynak y., YUCESAN F. B., ÖREM C.

Food and Health, vol.9, no.3, pp.201-211, 2023 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.3153/fh23019
  • Journal Name: Food and Health
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.201-211
  • Karadeniz Technical University Affiliated: Yes

Abstract

Oxidative modifications of lipoproteins are crucial in the early stages of cardiovascular diseases (CVD) like hypercholesterolemia. The major aim is to determine the effects of hazelnut consump- tion on the resistance of low- and high-density lipoproteins to oxidation in hypercholesterolemic subjects. Fifteen hypercholesterolemic subjects (13 men, 2 women) who did not require drug tre- atment according to the National Cholesterol Education Program Adult Treatment Panel III criteria and had serum levels of TC˃200 mg/dL were included in the study. This study was designed as a dual control sandwich model intervention with a single group, isoenergetic three periods. The pe- riods were; Control Diet I (30 days), Hazelnut-Enriched Diet (30 days), and Control Diet II (30 days). The susceptibility of LDL and HDL to copper-mediated oxidation was determined spect- rophotometrically by following conjugated diene formation. The resistance of lipoproteins, mainly LDL, was increased by hazelnut consumption. It can be concluded that a hazelnut-enriched diet had protective effects against lipoprotein oxidation in hypercholesterolemic subjects. These chan- ges may play important roles in reducing the development of the atherosclerotic process.