The Effects of high fat diets with and without N-Acetylcysteine supplementation on the lipin-1 levels of serum and various tissues in rats

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Kural B. V., ALVER A., Canpolat S., Kahraman C., Altay D. U., Kara H., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.39, no.1, pp.19-24, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.5505/tjb.2014.78941
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.19-24
  • Keywords: N-acetylcysteine, high fat diet, low fat diet, lipin-1, obesity, rat, OXIDATIVE STRESS, EXPRESSION, INFLAMMATION, PHOSPHATASE, METABOLISM, INCREASES, CYSTEINE, WHITE
  • Karadeniz Technical University Affiliated: Yes

Abstract

Objective: Obesity is a public health problem, but the struggle against obesity continues to increase every day. Lipin-1 is an adipokine that modulates lipid metabolism and glucose homeostasis. The aims of the current study were to compare the levels of lipin-1 in serum and tissues (liver, lung, heart, pancreas and kidney) in rat fed with low fat diet (LFD), high fat diet (HFD) and N-acetylcysteine (NAC) supplemented HFD, and to determine the relationships of the lipin-1 levels in serum and tissues with the levels of serum glucose and lipid parameters.