Paget's Disease Diagnosed on Cranial and Sacroiliac Involvement in Contrast to Normal Alkaline Phosphatase Levels

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Saglam G.

TURK OSTEOPOROZ DERGISI-TURKISH JOURNAL OF OSTEOPOROSIS, cilt.26, sa.2, ss.136-138, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tod.galenos.2019.15046
  • Dergi Adı: TURK OSTEOPOROZ DERGISI-TURKISH JOURNAL OF OSTEOPOROSIS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.136-138
  • Anahtar Kelimeler: Paget's disease, alkaline phosphatase, bone scintigraphy, ZOLEDRONIC ACID, BONE TURNOVER
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Paget's disease of bone is characterized by a chronic focal bone remodelling disorder, which is usually detected incidentally during routine imagining examinations. Although the measurement of total serum alkaline phosphatase usually provides a general indication of bone turnover in Paget's disease, about 10-15% of patients present with alkaline phosphatase levels within the normal range. The treatment of symptomatic forms relies on bisphosphonates that are efficient in reducing the bone turnover. Here, I present the case of an 80-year-old man suffering from chronic low back pain, and diagnosed as Paget's disease, with normal serum alkaline phosphatase and bone-specific alkaline phosphatase levels.