Paget's Disease Diagnosed on Cranial and Sacroiliac Involvement in Contrast to Normal Alkaline Phosphatase Levels


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Saglam G.

TURK OSTEOPOROZ DERGISI-TURKISH JOURNAL OF OSTEOPOROSIS, vol.26, no.2, pp.136-138, 2020 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.4274/tod.galenos.2019.15046
  • Title of Journal : TURK OSTEOPOROZ DERGISI-TURKISH JOURNAL OF OSTEOPOROSIS
  • Page Numbers: pp.136-138
  • Keywords: Paget's disease, alkaline phosphatase, bone scintigraphy, ZOLEDRONIC ACID, BONE TURNOVER

Abstract

Paget's disease of bone is characterized by a chronic focal bone remodelling disorder, which is usually detected incidentally during routine imagining examinations. Although the measurement of total serum alkaline phosphatase usually provides a general indication of bone turnover in Paget's disease, about 10-15% of patients present with alkaline phosphatase levels within the normal range. The treatment of symptomatic forms relies on bisphosphonates that are efficient in reducing the bone turnover. Here, I present the case of an 80-year-old man suffering from chronic low back pain, and diagnosed as Paget's disease, with normal serum alkaline phosphatase and bone-specific alkaline phosphatase levels.