Tooth transposition is a rare dental anomaly that is characterized by the interchanged position of two adjacent permanent teeth in the same quadrant or ectopic eruption of one tooth in the place of another. This article presents two case reports of transpositions. In the first case, a 21-year-old man presented with a left maxillary canine to molar site transposition. Radiographs showed that the canine was transposed completely. In the second case, a 35-year-old man presented with a right mandibular second premolar that had erupted between the first and second molars. Radiographs showed that the second premolar was positioned between the first and second molars. Maxillary canine to first molar site transpositions are extremely rare. To date, just eight cases have been reported in the English literature. Early loss of the first permanent molar may trigger distal migration of a developing canine bud. A mandibular second premolar erupting between the first and second molars is also a rare position anomaly that has not been reported in the English literature.