L-theanine alleviates liver and kidney dysfunction in septic rats induced by cecal ligation and puncture

Malkoç M., Patan H., Özer Yaman S., Türedi S., Kerimoğlu G., Kural B., ...More

LIFE SCIENCES, vol.249, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 249
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2020.117502
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: L-theanine, Sepsis, CLP, Oxidative stress, Inflammation, Apoptosis, EXPERIMENTAL SEPSIS, OXIDATIVE STRESS, INJURY, GLYCINE, INFLAMMATION, CYTOKINES, GREEN, ACID
  • Karadeniz Technical University Affiliated: Yes

Abstract

Aims: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response against infection that triggers systemic inflammatory response syndrome. L-theanine (LT), a glutamate derivative, is a non-protein amino acid derived from tea (Camellia sinensis), and a valuable nutraceutical product used as an additive in the food industry. This study we aimed to investigate whether LT would exert any therapeutic effect on liver and kidney tissues in Sprague Dawley rats with sepsis induced with cecal ligation and puncture (CLP).