Neutropenia and Thrombocytopenia Induced By Quetiapine Monotherapy: A Case Report and Review of Literature

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CİVİL ARSLAN F., SAĞLAM AYKUT D., Ince C., Tiryaki A.

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, cilt.26, sa.3, ss.319-323, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 26 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5455/bcp.20151219072235
  • Dergi Adı: KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.319-323
  • Anahtar Kelimeler: Quetiapine, neutropenia, thrombocytopenia, INDUCED LEUKOPENIA, VALPROATE, PATIENT, GRANULOCYTOPENIA, COMEDICATION, CLOZAPINE, XR
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Antipsychotic drugs can cause neutropenia which can progress to life-threatening agranulocytosis. Clozapine is well-known for this side effect which is rare for other antipsychotics. Quetiapine is a newer atypical antipsychotic which shows similarities with clozapine in chemical structure. We present a rare case of neutropenia and thrombocytopenia induced by quetiapine monotherapy of 600 mg/day in a 69-year old patient with the diagnosis of bipolar I disorder. Hematological adverse effects were resolved by the discontinuation of quetiapine treatment. Although monitoring blood counts during quetiapine use is not recommended, clinicians should be aware of this rare but hazardous side effect.