Hormonal and histological changes in the ovaries with high-doses of methylprednisolone administration for acute spinal cord injury: An experimental study

OSMANAĞAOĞLU M. A., USUL H., YULUĞ E., KESIM M., KARAHAN S. C.

Journal of Obstetrics and Gynaecology, cilt.33, sa.6, ss.585-590, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/01443615.2013.789833
  • Dergi Adı: Journal of Obstetrics and Gynaecology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.585-590
  • Anahtar Kelimeler: Methylprednisolone, ovarian damage, ovarian reserve, rats, spinal cord injury, LIPID-PEROXIDATION, TIRILAZAD MESYLATE, GLUCOCORTICOIDS, EXPRESSION, MELATONIN
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

This study was conducted to investigate the hormonal and histological changes in the ovaries with high doses of methylprednisolone administration for acute spinal cord injury (SCI). Group I (trauma group, eight rats) were subjected to laminectomy and SCI but received no treatment. Group II (steroid group, eight rats) were subjected to SCI and received methylprednisolone (30 mg/kg, intraperitoneally). Group III (control group, six rats) underwent a sham operation without trauma and treatment. Malondialdehyde (MDA) levels were significantly decreased in Group II (p < 0.05). The scores of histopathological damage of the ovaries in the three groups were found to be statistically comparable (p > 0.05). Serum anti-Müllerian hormone (AMH) levels in the steroid group was significantly lower compared with the control group (p < 0.05). High-dose methylprednisolone administration may effect ovarian reserve with reversible ovarian damage and can resolve lipid peroxidation in rats with spinal cord injury. © 2013 Informa UK, Ltd.