Mesoscopic Fluorescence Tomography of a Photosensitizer (HPPH) 3D Biodistribution in Skin Cancer

Ozturk M. S., ROHRBACH D., SUNAR U., Intes X.

ACADEMIC RADIOLOGY, cilt.21, sa.2, ss.271-280, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.acra.2013.11.009
  • Dergi Adı: ACADEMIC RADIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.271-280
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Rationale and Objectives: Photodynamic therapy (PDT) is a promising strategy for treating cancer. PDT involves three components: a photosensitizer (PS) drug, a specific wavelength of drug-activating light, and oxygen. A challenge in PDT is the unknown biodistribution of the PS in the target tissue. In this preliminary study, we report the development of a new approach to image in three dimensions the PS biodistribution in a noninvasive and fast manner.