Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level

ULUSOY Ş., Özkan G., MENTEŞE A., YAVUZ A., KARAHAN S. C., Sumer A. U.

CLINICAL BIOCHEMISTRY, cilt.45, ss.1444-1449, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.clinbiochem.2012.07.103
  • Dergi Adı: CLINICAL BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1444-1449
  • Anahtar Kelimeler: Hemodialysis, SCUBE1, sCD40L, Signal peptide-CUB-EGF domain-containing protein 1, ACUTE CORONARY SYNDROME, FACTOR-RELATED GENE, PLATELET ACTIVATION, EXPRESSION, LIGAND, COAGULATION, CD40, GLYCOPROTEINS, MORTALITY, DISEASE
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)domain-containing protein 1 (SCUBE1) is a cell surface protein belonging to the SCUBE gene family. SCUBE1 has been shown to rise in parallel with platelet activation in acute ischemic events. However, there are no studies showing levels in the hemodialysis patient group, in which there is known to be an increase in platelet function impairment and activation. The purpose of this study was to investigate SCUBE1 levels in a hemodialysis patient group and the factors affecting those levels.