In this study we present the structural vitreoretinal changes observed during the clinical follow-up of a 35-year-old female patient presenting with serous macular detachment complicated with active ocular toxoplasmosis. The patient applied to the ophthalmology outpatient clinic with the complaint of impaired vision in the left eye; during her clinical follow-up her active toxoplasma chorioretinitis and accompanying serous macular detachment (SMD) in the macula of the same eye were evaluated with optical coherence tomography (OCT). In the OCT sections encompassing the active lesion, there was increased reflectance and thickening in posterior hyaloid membrane and retinal layers as well as local fluid collection in the subretinal space. Secondary to increased retinal reflectance, retinal pigment epithelium-choriocapillaris junction demonstrated focal shadowing. The clinical findings of the patient improved with treatment. During her control OCT examination, it was seen that posterior hyaloid membrane at the site of the lesion was detached, collected fluid underneath the retina was resolved, retinal tissue became thinner with irregular layers and the suppressed reflectance of the retinal pigment epithelium-choriocapillaris junction was partially improved. OCT sections at the level of macula demonstrated total disappearance of SMD.