Plasma endothelin-1 levels in Behcet's disease


Uslu T., Erem C. , Tosun M., Deger O.

CLINICAL RHEUMATOLOGY, vol.16, no.1, pp.59-61, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 1997
  • Doi Number: 10.1007/bf02238764
  • Title of Journal : CLINICAL RHEUMATOLOGY
  • Page Numbers: pp.59-61

Abstract

Plasma concentrations of endothelin-1(ET-1), a vasoconstrictor peptide released from vascular endothelial and synovial cells, were measured by radioimmunoassay in 27 patients with Behcet's disease (ED) and 18 healthy controls, The plasma ET-1 concentrations were found to be significantly increased in patients with ED (121.15+/-11.6 fmol/dl) compared with the healthy subjects (89.37+/-8.03 fmol/dl p <0.05). The elevation of ET-1 did not correlate with the disease duration, gender, ocular off articular involvement, Whether the elevated ET-1 level is a direct result of its increased synthesis from injured vascular endothelial cells or whether its presence in high concentrations may be responsible, together with other factors for both vascular and articular complications in patients with BD is uncertain.