Plasma endothelin-1 levels in Behcet's disease

Uslu T., Erem C., Tosun M., Deger O.

CLINICAL RHEUMATOLOGY, vol.16, no.1, pp.59-61, 1997 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 1997
  • Doi Number: 10.1007/bf02238764
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.59-61
  • Karadeniz Technical University Affiliated: Yes


Plasma concentrations of endothelin-1(ET-1), a vasoconstrictor peptide released from vascular endothelial and synovial cells, were measured by radioimmunoassay in 27 patients with Behcet's disease (ED) and 18 healthy controls, The plasma ET-1 concentrations were found to be significantly increased in patients with ED (121.15+/-11.6 fmol/dl) compared with the healthy subjects (89.37+/-8.03 fmol/dl p <0.05). The elevation of ET-1 did not correlate with the disease duration, gender, ocular off articular involvement, Whether the elevated ET-1 level is a direct result of its increased synthesis from injured vascular endothelial cells or whether its presence in high concentrations may be responsible, together with other factors for both vascular and articular complications in patients with BD is uncertain.