Plasma endothelin-1 levels in Behcet's disease

Uslu T., Erem C. , Tosun M., Deger O.

CLINICAL RHEUMATOLOGY, cilt.16, sa.1, ss.59-61, 1997 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Konu: 1
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1007/bf02238764
  • Sayfa Sayıları: ss.59-61


Plasma concentrations of endothelin-1(ET-1), a vasoconstrictor peptide released from vascular endothelial and synovial cells, were measured by radioimmunoassay in 27 patients with Behcet's disease (ED) and 18 healthy controls, The plasma ET-1 concentrations were found to be significantly increased in patients with ED (121.15+/-11.6 fmol/dl) compared with the healthy subjects (89.37+/-8.03 fmol/dl p <0.05). The elevation of ET-1 did not correlate with the disease duration, gender, ocular off articular involvement, Whether the elevated ET-1 level is a direct result of its increased synthesis from injured vascular endothelial cells or whether its presence in high concentrations may be responsible, together with other factors for both vascular and articular complications in patients with BD is uncertain.