Non-aggregated and water soluble non-peripherally octa substituted Co(II) and Cu(II) phthalocyanines: Synthesis and α-glucosidase inhibitory effects

BIYIKLIOĞLU Z., Bas H., SEYHAN G., BARUT B.

JOURNAL OF INORGANIC BIOCHEMISTRY, cilt.257, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 257
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.jinorgbio.2024.112581
  • Dergi Adı: JOURNAL OF INORGANIC BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Veterinary Science Database
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Type 2 diabetes (T2DM) is a progressive metabolic disease associated with high blood sugar levels that affects 537 million people worldwide. This study aim is to investigate the potential for use in the treatment of T2DM by examining the in vitro glucosidase inhibitory effects of novel synthesized metallophthalocyanines. For this reason, we have synthesized cobalt(II), copper(II) phthalocyanines (3PY-ON-CoQ, 3PY-ON-CuQ) that are both water -soluble and do not aggregate in water. These compounds were characterized by using various spectroscopic methods. The alpha-glucosidase inhibitory properties of 3PY-ON-CoQ and 3PY-ON-CuQ were carried out using the spectrophotometric method. Then, Lineweaver-Burk and Dixon plots were examined to determine the inhibitory type and constant ( K i ). The IC 50 values of 3PY-ON-CoQ and 3PY-ON-CuQ were 6.85 +/- 1.25 mu M and 55.09 +/- 2.64 mu M, respectively. Both compounds displayed mixed inhibitory effects on alpha-glucosidase according to Lineweaver-Burk plots. The K i values of 3PY-ON-CoQ and 3PY-ON-CuQ were calculated as 6.30 +/- 1.55 mu M and 54.25 +/- 1.20 mu M, respectively. The results of this work may lead to the discovery of new compounds for the treatment of T2DM.