Effects of topiramate on adipocyte differentiation and gene expression of certain carbonic anhydrase isoenzymes

SÜMER A., Keha E. E., MENTEŞE A., ALVER A.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.45, no.2, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.1515/tjb-2019-0067
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Keywords: 3T3-L1 cells, Adipocyte differentiation, Carbonic anhydrase, Obesity, Topiramate, WEIGHT-LOSS, COMBINATION, INHIBITORS, ENERGY
  • Karadeniz Technical University Affiliated: Yes

Abstract

Background: Topiramate, an antiepileptic drug, besides its known effects in neurons, is a carbonic anhydrase inhibitor and causes weight loss in treated subjects, but, the mechanisms of weight loss effect have not been yet identified..