Synthesis of novel Schiff bases and azol-beta-lactam derivatives starting from morpholine and thiomorpholine and investigation of their antitubercular, antiurease activity, acethylcolinesterase inhibition effect and antioxidant capacity


CEBECI Y. U. , BAYRAK H., ŞIRIN Y.

BIOORGANIC CHEMISTRY, vol.88, 2019 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 88
  • Publication Date: 2019
  • Doi Number: 10.1016/j.bioorg.2019.102928
  • Journal Name: BIOORGANIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: Schiff base, beta-Lactam, Morpholine, Thiomorpholine, Azole, Antitubercular activity, Antiurease activity, Acethylcolinesterase, Antioxidant, BIOLOGICAL EVALUATION, ANTIBACTERIAL, PRODUCTS, DRUG

Abstract

In this study, new Schiff bases and beta-lactam derivatives containing morpholine and thio morpholine nuclei were synthesized. Antimicrobial, antioxidant, antimicrobial and antioxidant properties of all synthesized compounds were investigated and highly effective products were obtained. In this context, new effective structures were introduced to the literature.