Synthesis of novel Schiff bases and azol-beta-lactam derivatives starting from morpholine and thiomorpholine and investigation of their antitubercular, antiurease activity, acethylcolinesterase inhibition effect and antioxidant capacity

CEBECI, Yildiz; BAYRAK, HACER; ŞIRIN, Yakup

doi:10.1016/j.bioorg.2019.102928

Synthesis of novel Schiff bases and azol-beta-lactam derivatives starting from morpholine and thiomorpholine and investigation of their antitubercular, antiurease activity, acethylcolinesterase inhibition effect and antioxidant capacity

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CEBECI Y. U., BAYRAK H., ŞIRIN Y.

BIOORGANIC CHEMISTRY, vol.88, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 88
Publication Date: 2019
Doi Number: 10.1016/j.bioorg.2019.102928
Journal Name: BIOORGANIC CHEMISTRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: Schiff base, beta-Lactam, Morpholine, Thiomorpholine, Azole, Antitubercular activity, Antiurease activity, Acethylcolinesterase, Antioxidant, BIOLOGICAL EVALUATION, ANTIBACTERIAL, PRODUCTS, DRUG
Karadeniz Technical University Affiliated: Yes

Abstract

In this study, new Schiff bases and beta-lactam derivatives containing morpholine and thio morpholine nuclei were synthesized. Antimicrobial, antioxidant, antimicrobial and antioxidant properties of all synthesized compounds were investigated and highly effective products were obtained. In this context, new effective structures were introduced to the literature.