Does Blood Glucose Regulation in Adults with Type 2 Diabetes Affect Exocrine Pancreatic Functions?

Creative Commons License

Fidan S. , Kişioğlu S. V. , Buruk C. K. , Ateş E. , Coşar A. M. , Ersöz H. Ö. , ...Daha Fazla

Turkish Journal of Endocrinology and Metabolism, cilt.25, ss.87-94, 2021 (ESCI İndekslerine Giren Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25
  • Basım Tarihi: 2021
  • Doi Numarası: 10.25179/tjem.2020-79839
  • Dergi Adı: Turkish Journal of Endocrinology and Metabolism
  • Sayfa Sayıları: ss.87-94


Objective: The purpose of this study was to assess the pos-
sible effects of blood glucose regulation on pancreatic exocrine
functions in type 2 diabetes mellitus (T2DM) patients with poor
glycemic control. Material and Methods: This prospective cli-
nical study was performed with 20 patients with poorly control-
led T2DM (HbA1c >10%) and age- and sex-matched 20 healthy
controls. At the beginning of the study, metabolic parameters
and fecal elastase-1 (FE-1) levels, one of the markers of pan-
creatic exocrine insufficiency (PEI), were compared between the
patient and control groups. In addition, after blood glucose re-
gulation was achieved with at least three months of intensive
insulin therapy in the patient group, FE-1 levels and metabolic
parameters were compared with pre-treatment. PEI was defi-
ned as FE-1 levels lower than 200 µg/g. Results: FE-1 levels
were significantly lower in the T2DM group than the control
group (median values for patients=333.1 µg/g and controls=
508.5 µg/g; p=0.013). PEI was detected in three patients
(15%) but none in the control group. After intensive insulin the-
rapy, T2DM patients FE-1 levels significantly increased compa-
red to their pre-treatment (pre-treatment median: 333.15
(192.60) µg/g, post-treatment median: 415.40 (300.77) µg/g;
p=0.044). The major factors impacting this increase were the
duration of diabetes and the change in HbA1c levels. Conclusi-
ons: FE-1 levels in patients with poorly controlled T2DM were
lower than the healthy control group, which significantly increa-
sed with blood glucose regulation.