ACTIONS OF CYCLOSPORINE-A PREPARATION AND CREMOPHOR-EL IN RABBIT MESENTERIC-ARTERY AND THORACIC AORTA INVITRO

YARIS E., TUNCER M., ILHAN M.

CLINICAL SCIENCE, vol.83, no.2, pp.179-182, 1992 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 2
  • Publication Date: 1992
  • Doi Number: 10.1042/cs0830179
  • Journal Name: CLINICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.179-182
  • Keywords: CREMOPHOR-EL, CYCLOSPORINE-A, ENDOTHELIUM-DEPENDENT RELAXATION, SUPERIOR MESENTERIC ARTERY, THORACIC AORTA, BLOOD-PRESSURE, TRANSPLANTATION, HYPERTENSION, RATS
  • Karadeniz Technical University Affiliated: No

Abstract

1. We studied the in vitro and direct effects of intravenous cyclosporin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acetylcholine-induced endothelium-dependent relaxation, phenylephrine-induced contraction and drug-induced contraction of rabbit thoracic aorta and superior mesenteric artery segments.