Urease Inhibition Studies of New Benzimidazoles Containing Triazole Ring
Russian Journal of General Chemistry, vol.93, no.2, pp.449-454, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 93 Issue: 2
- Publication Date: 2023
- Doi Number: 10.1134/s1070363223020287
- Journal Name: Russian Journal of General Chemistry
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Index Chemicus (IC)
- Page Numbers: pp.449-454
- Keywords: benzimidazoles, thiosemicarbazides, triazoles, urease inhibition
- Karadeniz Technical University Affiliated: Yes
Abstract
Abstract: A new series of benzimidazoles including triazole and thiosemicarbazide moieties was synthesized and their urease inhibition studies were evaluated according to the method of Van Slyke and Archibald. Especially triazole derivatives have effective inhibition activities between 0.04±0.026 and 0.26±0.042 µM IC50 values. The best antiurease activities with IC50 0.04±0.026 and 0.06±0.033 µM belongs to 5-[(5,6-dichloro-1H-benzimidazol-1-yl)methyl]-4-nitrophenyl-4H-1,2,4-triazole-3-thiol and 2-[(2-benzyl-5,6-dichloro-1H-benzimidazol-1-yl)acetyl]-N-(4-nitrophenyl)hydrazinecarbothioamide, respectively.