Relationship between Disease Activity and Absolute Eosinophil Count and Serum IgE Level in Pediatric Patients with Eosinophilic Esophagitis
GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS, vol.23, no.3, pp.206-212, 2025 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 23 Issue: 3
- Publication Date: 2025
- Doi Number: 10.4274/jcp.2025.04378
- Journal Name: GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Page Numbers: pp.206-212
- Karadeniz Technical University Affiliated: Yes
Abstract
Introduction: Clinical improvement does not reflect mucosal healing in the evaluation of response to treatment in eosinophilic esophagitis (EoE), and thus repeated endoscopies and eosinophil count on esophageal biopsy are still needed. Given that endoscopy is an invasive, risky, and costly method, noninvasive biomarkers that could practically indicate inflammation are needed to evaluate the treatment response. Materials and Methods: The study included pediatric patients aged 0-18 years diagnosed with EoE. Age, gender, presenting complaints, comorbid allergic diseases, absolute eosinophil count (AEC), serum total IgE, and specific IgE (sIgE) levels were recorded retrospectively. All endoscopic examinations were performed by the same two experienced pediatric gastroenterologists. Biopsy samples were re-evaluated by two experienced pathologists. Results: The study included 30 patients comprising 25 (83.3%) boys and 5 (16.7%) girls with a mean age of 6.93 +/- 4.47 (range, 2-16) years. Esophageal eosinophilic density established no significant correlation with total IgE level (p=0.75), while it was correlated with AEC (p=0.005, r=0.248). Both IgE (1843.1 kU/L vs. 420.8 kU/L, p<0.05) and AEC (1073.8/