Relationship between Disease Activity and Absolute Eosinophil Count and Serum IgE Level in Pediatric Patients with Eosinophilic Esophagitis

GÜVEN B., Yilmaz S. A., SAĞNAK YILMAZ Z., SAYGIN İ., YILDIZ N., KARAKULLUKÇU S., ...Daha Fazla

GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS, cilt.23, sa.3, ss.206-212, 2025 (ESCI, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 3
  • Basım Tarihi: 2025
  • Doi Numarası: 10.4274/jcp.2025.04378
  • Dergi Adı: GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.206-212
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Introduction: Clinical improvement does not reflect mucosal healing in the evaluation of response to treatment in eosinophilic esophagitis (EoE), and thus repeated endoscopies and eosinophil count on esophageal biopsy are still needed. Given that endoscopy is an invasive, risky, and costly method, noninvasive biomarkers that could practically indicate inflammation are needed to evaluate the treatment response. Materials and Methods: The study included pediatric patients aged 0-18 years diagnosed with EoE. Age, gender, presenting complaints, comorbid allergic diseases, absolute eosinophil count (AEC), serum total IgE, and specific IgE (sIgE) levels were recorded retrospectively. All endoscopic examinations were performed by the same two experienced pediatric gastroenterologists. Biopsy samples were re-evaluated by two experienced pathologists. Results: The study included 30 patients comprising 25 (83.3%) boys and 5 (16.7%) girls with a mean age of 6.93 +/- 4.47 (range, 2-16) years. Esophageal eosinophilic density established no significant correlation with total IgE level (p=0.75), while it was correlated with AEC (p=0.005, r=0.248). Both IgE (1843.1 kU/L vs. 420.8 kU/L, p<0.05) and AEC (1073.8/L vs. 436.3/mu L, p<0.05) were found to be significantly higher in patients with eosinophilic microabscess. In ROC analysis, AEC was found to have a predictive value in the diagnosis of EoE (AUC: 0.609, 95% CI: 0.51-0.71, p=0.022) at a cut-off value of 395/L, with a sensitivity, specificity, PPV, and NPV of 58.1%, 64.2%, 47.5%, and 53.5%, respectively. Conclusion: Although AEC appears to be a usable parameter in the follow-up of the patients, it is not sufficient as a biomarker alone for the prediction of EoE.