Azometin Grup İçeren Yeni Ligandların Sentezi ve Antioksidant, Antiüreaz Aktivitelerinin İncelenmesi


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Gümrükçüoğlu N. , Bilgin Sökmen B.

Gazi University Journal of Science, cilt.33, ss.662-671, 2020 (ESCI İndekslerine Giren Dergi)

  • Cilt numarası: 33 Konu: 3
  • Basım Tarihi: 2020
  • Dergi Adı: Gazi University Journal of Science
  • Sayfa Sayıları: ss.662-671

Özet

A series of Schiff base ligands containing 1,2,4-triazole ring were obtained by the addition of aldehydes to the amino compound under mild conditions in 80–82% yields. A reduction of these ligands with sodium borohydride resulted in Schiff base reduction products. New ligands were investigated for their antioxidant activities such as DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2’-azino-bis (3-ethylbenzo-thizoline-6-sulphonic acid) diammonium salt) radical scavenging and reducing power. 1H and 13C-NMR spectra (δ, ppm) were observed on a Varian Mercury 200 MHz spectrophotometer as standard substance using tetramethylsilane Match constants (J values) were given as Hertz. NMR coefficients are truncated as follows: s=singlet, d=dublet, t=triplet, m=multiplet signal. Combustion analysis was performed on a Carlo Erba 1106 elemental analyzer. All the compounds gave C, H, and N analysis results within ±0.6 % of the theoretical values. The IR spectra (υ, cm−1) were viewed with a Perkin-Elmer 1600 FTIR spectrometer in KBr pellets.