A multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in IMRT era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (TROD 01-001)

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Yildirim H. C., Kupik G. E., Mustafayev T. Z., Berber T., Yavuz B., Cetinayak O., ...Daha Fazla

Head and Neck, cilt.45, sa.5, ss.1194-1205, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 5
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/hed.27333
  • Dergi Adı: Head and Neck
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1194-1205
  • Anahtar Kelimeler: chemoradiotherapy, EBV-DNA, intensity-modulated radiotherapy, nasopharyngeal carcinoma, nonendemic, INTENSITY-MODULATED RADIOTHERAPY, AJCC/UICC STAGING SYSTEM, CONCURRENT CHEMORADIOTHERAPY, 8TH EDITION, CHEMOTHERAPY, DNA, VALIDATION, WORLDWIDE, OUTCOMES, TRIALS
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Background: We aimed to evaluate patients with nasopharyngeal carcinoma (NPC) in a nonendemic population. Methods: In a national, retrospective, multicenteric study, 563 patients treated with intensity modulated radiotherapy at 22 centers between 2015 and 2020 were analyzed. Results: Median age was 48 (9–83), age distribution was bimodal, 74.1% were male, and 78.7% were stage III-IVA. Keratinizing and undifferentiated carcinoma rates were 3.9% and 81.2%. Patients were treated with concomitant chemoradiotherapy (48.9%), or radiotherapy combined with induction chemotherapy (25%) or adjuvant chemotherapy (19.5%). After 34 (6–78) months follow-up, 8.2% locoregional and 8% distant relapse were observed. Three-year overall survival was 89.5% and was lower in patients with age ≥50, male sex, keratinizing histology, T4, N3 and advanced stage (III-IVA). Conclusions: Patients with NPC in Turkey have mixed clinical features of both east and west. Survival outcomes are comparable to other reported series; however, the rate of distant metastases seems to be lower.