In vitro biological activity of some new 1,2,4-triazole derivatives with their potentiometric titrations

Aktas-Yokus O., Yuksek H., Manap S., Aytemiz F., Alkan M., Beytur M., ...Daha Fazla

BULGARIAN CHEMICAL COMMUNICATIONS, ss.98-106, 2017 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2017
  • Dergi Adı: BULGARIAN CHEMICAL COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.98-106
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

In this study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2 have been reacted with 3-(4-methoxybenzenesulfonyloxy)-4-methoxybenzaldehyde 1 to afford the corresponding nine new 3-alkyl(aryl)-4-[ 3-(4methoxybenzenesulfonyloxy)-4-methoxybenzylideneamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones 3. The structures of nine new compounds have been characterized by IR, H-1 and C-13 NMR spectral data. The synthesized compounds have been analyzed for their in vitro antioxidant and antimicrobial activities. Furthermore, the half-neutralization potential values and the corresponding pK(a) values were determined for all the newly synthesized compounds.