In vitro biological activity of some new 1,2,4-triazole derivatives with their potentiometric titrations
BULGARIAN CHEMICAL COMMUNICATIONS, pp.98-106, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Publication Date: 2017
- Journal Name: BULGARIAN CHEMICAL COMMUNICATIONS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.98-106
- Karadeniz Technical University Affiliated: No
Abstract
In this study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2 have been reacted with 3-(4-methoxybenzenesulfonyloxy)-4-methoxybenzaldehyde 1 to afford the corresponding nine new 3-alkyl(aryl)-4-[ 3-(4methoxybenzenesulfonyloxy)-4-methoxybenzylideneamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones 3. The structures of nine new compounds have been characterized by IR, H-1 and C-13 NMR spectral data. The synthesized compounds have been analyzed for their in vitro antioxidant and antimicrobial activities. Furthermore, the half-neutralization potential values and the corresponding pK(a) values were determined for all the newly synthesized compounds.