The efficacy of octreotide in the therapy of acute radiation-induced diarrhea: A randomized controlled study


YAVUZ M., YAVUZ A., Aydin F., Can G., Kavgaci H.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol.54, no.1, pp.195-202, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1016/s0360-3016(02)02870-5
  • Journal Name: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.195-202
  • Keywords: pelvic radiation therapy, radiation-induced diarrhea, octreotide, CHEMOTHERAPY-INDUCED DIARRHEA, ACTING SOMATOSTATIN ANALOG, BONE-MARROW TRANSPLANT, SMS 201-995, LOPERAMIDE, ACETATE, PATIENT, TRIAL, SMS-201-995, SANDOSTATIN
  • Karadeniz Technical University Affiliated: Yes

Abstract

Purpose: Although the somatostatin analog octreotide is currently used in the treatment of chemotherapy-induced diarrhea and secretory diarrhea associated with various disorders, its role in the management of radiation enteritis is not well defined. We performed a randomized study that compared octreotide acetate with diphenoxylate hydrochloride plus atropine sulfate, the drug commonly used as therapy for acute radiation-induced diarrhea (ARID).