The efficacy of octreotide in the therapy of acute radiation-induced diarrhea: A randomized controlled study
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol.54, no.1, pp.195-202, 2002 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 54 Issue: 1
- Publication Date: 2002
- Doi Number: 10.1016/s0360-3016(02)02870-5
- Journal Name: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.195-202
- Keywords: pelvic radiation therapy, radiation-induced diarrhea, octreotide, CHEMOTHERAPY-INDUCED DIARRHEA, ACTING SOMATOSTATIN ANALOG, BONE-MARROW TRANSPLANT, SMS 201-995, LOPERAMIDE, ACETATE, PATIENT, TRIAL, SMS-201-995, SANDOSTATIN
- Karadeniz Technical University Affiliated: Yes
Abstract
Purpose: Although the somatostatin analog octreotide is currently used in the treatment of chemotherapy-induced diarrhea and secretory diarrhea associated with various disorders, its role in the management of radiation enteritis is not well defined. We performed a randomized study that compared octreotide acetate with diphenoxylate hydrochloride plus atropine sulfate, the drug commonly used as therapy for acute radiation-induced diarrhea (ARID).