Development of low-cost, fast, and sensitive voltammetric methods for the determination of donepezil using unmodified carbon paste electrode

ÖZTÜRK G., Sofu U., KUL D.

MONATSHEFTE FUR CHEMIE, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s00706-024-03264-7
  • Dergi Adı: MONATSHEFTE FUR CHEMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Novel voltammetric methods were developed for the determination of donepezil, an acetylcholinesterase inhibitor, using the prepared carbon paste electrode. As a result of the optimization, the carbon paste composition was determined as 25% mineral oil and 75% graphite powder. Quantitative analysis of donepezil was carried out by differential pulse voltammetry (DPV) or square wave voltammetry (SWV) in Britton-Robinson buffer at pH 8.0. Linear ranges were obtained as 0.1-20 mu M with a detection limit of 26.3 nM for DPV and 0.08-10 mu M with a detection limit of 20.4 nM for SWV. The accuracy of the developed methods was obtained as 101.08% and 100.73% for DPV and SWV, respectively, with recovery from pharmaceutical dosage form, indicating that the determination of donepezil could be successfully accomplished without the interference of excipients.