4-Aminoantipyrine-derived Schiff base substituted novel symmetrical zinc (II) phthalocyanine photosensitizers: Design, synthesis, photophysical, and photochemical properties for photodynamic therapy of cancer

YALAZAN H., Ömeroğlu İ., Durmuş M., KANTEKİN H.

INORGANIC CHEMISTRY COMMUNICATIONS, cilt.181, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 181
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.inoche.2025.115125
  • Dergi Adı: INORGANIC CHEMISTRY COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, DIALNET
  • Anahtar Kelimeler: 4-Aminoantipyrine, Photochemical, Photodynamic therapy, Photophysical, Phthalocyanine, Schiff base
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

In this study, new Zn-phthalocyanine compounds (ANTS-ZnPcsp/np), peripherally and non-peripherally substituted with 4-aminoantipyrine-derived Schiff base, were synthesized and characterized by FT-IR, NMR, MALDI-TOF, and UV-Vis spectroscopic techniques. The photophysical and photochemical properties of these compounds were investigated. The fluorescence quantum yield values were found to be 0.11 and 0.05 in DMSO for ANTS-ZnPcp and ANTS-ZnPcnp, respectively. The singlet oxygen quantum yield values of these phthalocyanines were obtained as 0.53 for ANTS-ZnPcp and 0.27 for ANTS-ZnPcnp. According to the results, both phthalocyanine derivatives are considered to be suitable photosensitizers for cancer treatment by photodynamic therapy (PDT) method.