4-Aminoantipyrine-derived Schiff base substituted novel symmetrical zinc (II) phthalocyanine photosensitizers: Design, synthesis, photophysical, and photochemical properties for photodynamic therapy of cancer
INORGANIC CHEMISTRY COMMUNICATIONS, vol.181, 2025 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 181
- Publication Date: 2025
- Doi Number: 10.1016/j.inoche.2025.115125
- Journal Name: INORGANIC CHEMISTRY COMMUNICATIONS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, DIALNET
- Keywords: 4-Aminoantipyrine, Photochemical, Photodynamic therapy, Photophysical, Phthalocyanine, Schiff base
- Karadeniz Technical University Affiliated: Yes
Abstract
In this study, new Zn-phthalocyanine compounds (ANTS-ZnPcsp/np), peripherally and non-peripherally substituted with 4-aminoantipyrine-derived Schiff base, were synthesized and characterized by FT-IR, NMR, MALDI-TOF, and UV-Vis spectroscopic techniques. The photophysical and photochemical properties of these compounds were investigated. The fluorescence quantum yield values were found to be 0.11 and 0.05 in DMSO for ANTS-ZnPcp and ANTS-ZnPcnp, respectively. The singlet oxygen quantum yield values of these phthalocyanines were obtained as 0.53 for ANTS-ZnPcp and 0.27 for ANTS-ZnPcnp. According to the results, both phthalocyanine derivatives are considered to be suitable photosensitizers for cancer treatment by photodynamic therapy (PDT) method.