Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation

Karakas D., Cevatemre B., ORAL H. B., YILMAZ V. T., Ulukaya E.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.19, no.9, pp.1184-1195, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 9
  • Publication Date: 2019
  • Doi Number: 10.2174/1871520619666190409103334
  • Journal Name: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1184-1195
  • Keywords: Prostate cancer, cytotoxicity, apoptosis, oxidative stress, unfolded protein response, platinum(II) complex, ENDOPLASMIC-RETICULUM STRESS, HISTONE H2AX PHOSPHORYLATION, N-TERMINAL KINASE, OXIDATIVE STRESS, IN-VITRO, STRUCTURAL-CHARACTERIZATION, CRYSTAL-STRUCTURE, ER STRESS, DNA, DESIGN
  • Karadeniz Technical University Affiliated: No

Abstract

Background: Prostate cancer is one of the most common cancer types and it is the sixth leading cause of cancer-related death in men worldwide. Even though novel treatment modalities have been developed, it still a lifethreatening disease. Therefore novel compounds are needed to improve the overall survival.