Demonstration of technical feasibility and viability of whole eye transplantation in a rodent model

Zor F., Polat M., Kulahci Y., Sahin H., Aral A. M., Erbas V. E., ...Daha Fazla

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, cilt.72, sa.10, ss.1640-1650, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 10
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.bjps.2019.05.042
  • Dergi Adı: JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1640-1650
  • Anahtar Kelimeler: Whole eye transplantation, immunology, rejection, optic nerve, vision restoration, vascularized composite allotransplantation, immunosuppression, nerve regeneration, RETINAL GANGLION-CELLS, ISCHEMIA-REPERFUSION INJURY, PERIPHERAL-NERVE GRAFTS, OPTIC-NERVE, VISUAL IMPAIRMENT, ALLOTRANSPLANTATION MODEL, GLOBAL PREVALENCE, VISION IMPAIRMENT, TEMPORAL-TRENDS, BLINDNESS
  • Karadeniz Teknik Üniversitesi Adresli: Hayır

Özet

Introduction: Whole eye transplantation (WET) holds promise for vision restoration in devastating/disabling visual loss (congenital or traumatic) not amenable to surgical or neuroprosthetic treatment options. The eye includes multiple tissues with distinct embryonic lineage and differential antigenicity. Anatomically and immunologically, the eye is unique due to its avascular (cornea) and highly vascular (retina) components. Our goal was to establish technical feasibility, demonstrate graft viability, and evaluate histologic changes in ocular tissues/adnexae in a novel experimental model of WET that included globe, adnexal, optic nerve (ON), and periorbital soft tissues.