Susac Syndrome: Clinical characteristics, diagnostic findings and treatment in 19 cases

Karahan S. Z., Boz C., Saip S., Kale N., Demirkaya S., Celik Y., ...Daha Fazla

MULTIPLE SCLEROSIS AND RELATED DISORDERS, cilt.33, ss.94-99, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 33
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.msard.2019.05.018
  • Dergi Adı: MULTIPLE SCLEROSIS AND RELATED DISORDERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.94-99
  • Anahtar Kelimeler: Susac Syndrome, Corpus callosum, Branch retinal artery occlusion
  • Karadeniz Teknik Üniversitesi Adresli: Evet

Özet

Susac's Syndrome (SS), which was first described in 1979, is a rare and presumably autoimmune disorder characterized by encephalopathy, hearing loss, and visual disturbance resulting from branch retinal artery occlusion (BRAO). This study reports 19 SS patients' clinical characteristics, MRI features, CSF analysis, treatment strategies and outcomes. At initial presentation, only three of 19 patients demonstrated the complete clinical triad. Clinic presentation varied from isolated hemiparesis to the full triad (encephalopathy, hearing loss and visual disturbances). Corpus callosum (CC) involvement was noted in the MRI of 18 patients (97%) and BRAO was detected in 17 (95%) patients. All patients were treated with intravenous methylprednisolone after the initial assessment. This case series is presented to emphasize the differences in clinical presentation of SS and the importance of MRI and FFA in diagnosis.